Version 5.4
Mus musculus Gene: Hoxa11
Summary
InnateDB Gene IDBG-148062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxa11
Gene Name homeobox A11
Synonyms Hox-1.9; Hoxa-11
Species Mus musculus
Ensembl Gene ENSMUSG00000038210
Encoded Proteins
IDBP-148064
homeobox A11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:52242106-52245810
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000048026 ENSMUSP00000040920
ENSMUST00000131495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007501 mesodermal cell fate specification
GO:0008584 male gonad development
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0010468 regulation of gene expression
GO:0010720 positive regulation of cell development
GO:0030326 embryonic limb morphogenesis
GO:0032330 regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0035115 embryonic forelimb morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048589 developmental growth
GO:0060065 uterus development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060351 cartilage development involved in endochondral bone morphogenesis
Cellular Component
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005073
View Gene Order
ENSBTAG00000014738
Not yet available
Cross-References
SwissProt P31311
TrEMBL
UniProt Splice Variant
Entrez Gene 15396
UniGene Mm.26954
RefSeq NM_010450
OMIM
CCDS CCDS20148
HPRD
IMGT
MGI ID MGI:96172
MGI Symbol Hoxa11
EMBL AK133481 BC119302 U20370 U20371
GenPept AAA85710 AAA85711 AAI19303 BAE21679
RNA Seq Atlas 15396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca