Homo sapiens Gene: TNNI1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-105757.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TNNI1 | ||||||||||||||||||
Gene Name | troponin I type 1 (skeletal, slow) | ||||||||||||||||||
Synonyms | SSTNI; TNN1 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000159173 | ||||||||||||||||||
Encoded Proteins |
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:201403768-201429866 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q32.1 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Striated Muscle Contraction pathway
Muscle contraction pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | G3V489 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 7135 | ||||||||||||||||||
UniGene | Hs.320890 Hs.624052 | ||||||||||||||||||
RefSeq | NM_003281 | ||||||||||||||||||
HUGO | HGNC:11945 | ||||||||||||||||||
OMIM | 191042 | ||||||||||||||||||
CCDS | CCDS1411 | ||||||||||||||||||
HPRD | 01842 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC096677 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 7135 | ||||||||||||||||||