Mus musculus Gene: Tnni1 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-195053.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Tnni1 | ||||||
Gene Name | troponin I, skeletal, slow 1 | ||||||
Synonyms | 2700018B22Rik; AI747285; ssTnI | ||||||
Species | Mus musculus | ||||||
Ensembl Gene | ENSMUSG00000026418 | ||||||
Encoded Proteins |
troponin I, skeletal, slow 1
troponin I, skeletal, slow 1
troponin I, skeletal, slow 1
troponin I, skeletal, slow 1
troponin I, skeletal, slow 1
troponin I, skeletal, slow 1
troponin I, skeletal, slow 1
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159173:
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 1:135779434-135810989 | ||||||
Strand | Forward strand | ||||||
Band | E4 | ||||||
Transcripts | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||
NETPATH | |||||||
REACTOME |
Striated Muscle Contraction pathway
Muscle contraction pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Striated Muscle Contraction pathway
Muscle contraction pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Mm.44379 | ||||||
RefSeq | NM_001112702 NM_021467 | ||||||
OMIM | |||||||
CCDS | CCDS48374 | ||||||
HPRD | |||||||
IMGT | |||||||
MGI ID | |||||||
MGI Symbol | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||