InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LGR6

Summary

InnateDB Gene

IDBG-105832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGR6

Gene Name

leucine-rich repeat containing G protein-coupled receptor 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000133067

Encoded Proteins

IDBP-105834

leucine-rich repeat containing G protein-coupled receptor 6

IDBP-105840

leucine-rich repeat containing G protein-coupled receptor 6

IDBP-389894

leucine-rich repeat containing G protein-coupled receptor 6

IDBP-389895

leucine-rich repeat containing G protein-coupled receptor 6

IDBP-485595

leucine-rich repeat containing G protein-coupled receptor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:202193901-202319781

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000367278	ENSP00000356247
ENST00000255432	ENSP00000255432
ENST00000308543
ENST00000423542	ENSP00000402284
ENST00000439764	ENSP00000387869
ENST00000487787	ENSP00000422143
ENST00000503519
ENST00000506931

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0016055	Wnt signaling pathway
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030335	positive regulation of cell migration
GO:0090263	positive regulation of canonical Wnt signaling pathway