Version 5.4
Homo sapiens Gene: BTG2
Summary
InnateDB Gene IDBG-105945.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTG2
Gene Name BTG family, member 2
Synonyms PC3; TIS21
Species Homo sapiens
Ensembl Gene ENSG00000159388
Encoded Proteins
IDBP-105949
BTG family, member 2
IDBP-598918
BTG family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:203305491-203309602
Strand Forward strand
Band q32.1
Transcripts
ENST00000290551 ENSP00000290551
ENST00000475157 ENSP00000433553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006479 protein methylation
GO:0006974 cellular response to DNA damage stimulus
GO:0008285 negative regulation of cell proliferation
GO:0008306 associative learning
GO:0009612 response to mechanical stimulus
GO:0009952 anterior/posterior pattern specification
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0017148 negative regulation of translation
GO:0021542 dentate gyrus development
GO:0021954 central nervous system neuron development
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0035914 skeletal muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051602 response to electrical stimulus
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020423
View Gene Order
ENSBTAG00000015711
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt P78543
TrEMBL A0A024R986
UniProt Splice Variant
Entrez Gene 7832
UniGene Hs.519162 Hs.714182
RefSeq NM_006763
HUGO HGNC:1131
OMIM 601597
CCDS CCDS1437
HPRD
IMGT
EMBL AF361937 AL513326 BC105948 BC105949 CH471067 U72649 Y09943
GenPept AAB37580 AAI05949 AAI05950 AAL05626 CAA71074 CAH70451 EAW91475 EAW91476
RNA Seq Atlas 7832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca