Version 5.4
Mus musculus Gene: Btg2
Summary
InnateDB Gene IDBG-193322.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Btg2
Gene Name B cell translocation gene 2, anti-proliferative
Synonyms AA959598; APRO1; Pc3; TIS21
Species Mus musculus
Ensembl Gene ENSMUSG00000020423
Encoded Proteins
IDBP-193324
B-cell translocation gene 2, anti-proliferative
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159388:
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:134075170-134079120
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000020692 ENSMUSP00000020692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006479 protein methylation
GO:0006974 cellular response to DNA damage stimulus
GO:0008285 negative regulation of cell proliferation
GO:0008306 associative learning
GO:0009612 response to mechanical stimulus
GO:0009952 anterior/posterior pattern specification
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0017148 negative regulation of translation
GO:0021542 dentate gyrus development
GO:0021954 central nervous system neuron development
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0035914 skeletal muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051602 response to electrical stimulus
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159388
View Gene Order
ENSBTAG00000015711
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03018
RNA degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt Q04211
TrEMBL Q3TF68
UniProt Splice Variant
Entrez Gene 12227
UniGene Mm.392646 Mm.431424 Mm.487029
RefSeq NM_007570
OMIM
CCDS CCDS15302
HPRD
IMGT
MGI ID MGI:108384
MGI Symbol Btg2
EMBL AK133796 AK169269 AK169436 BC132259 BC138639 CH466520 M64292
GenPept AAA40449 AAI32260 AAI38640 BAE21847 BAE41030 BAE41177 EDL39630
RNA Seq Atlas 12227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca