InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FMOD

Summary

InnateDB Gene

IDBG-105950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMOD

Gene Name

fibromodulin

Synonyms

FM; SLRR2E

Species

Homo sapiens

Ensembl Gene

ENSG00000122176

Encoded Proteins

IDBP-105952

fibromodulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. [provided by RefSeq, Jul 2008]
Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:203340628-203351489

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000354955	ENSP00000347041
ENST00000493296
ENST00000461936

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007181	transforming growth factor beta receptor complex assembly
GO:0018146	keratan sulfate biosynthetic process
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0042340	keratan sulfate catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen