InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRELP

Summary

InnateDB Gene

IDBG-105955.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRELP

Gene Name

proline/arginine-rich end leucine-rich repeat protein

Synonyms

MST161; MSTP161; SLRR2A

Species

Homo sapiens

Ensembl Gene

ENSG00000188783

Encoded Proteins

IDBP-105957

proline/arginine-rich end leucine-rich repeat protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:203475828-203491352

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000343110

ENSP00000343924

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0001501	skeletal system development
GO:0005975	carbohydrate metabolic process
GO:0007569	cell aging
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0042340	keratan sulfate catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome