Version 5.4
Homo sapiens Gene: PIGR
Summary
InnateDB Gene IDBG-106295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGR
Gene Name polymeric immunoglobulin receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162896
Encoded Proteins
IDBP-106297
polymeric immunoglobulin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:206928518-206946466
Strand Reverse strand
Band q32.1
Transcripts
ENST00000356495 ENSP00000348888
ENST00000487208
ENST00000491503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001792 polymeric immunoglobulin receptor activity
GO:0005515 protein binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001895 retina homeostasis
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0038093 Fc receptor signaling pathway
GO:0043113 receptor clustering
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026417
View Gene Order
ENSBTAG00000019798
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P01833
TrEMBL
UniProt Splice Variant
Entrez Gene 5284
UniGene Hs.497589 Hs.709003
RefSeq NM_002644
HUGO HGNC:8968
OMIM 173880
CCDS CCDS1474
HPRD
IMGT
EMBL AF272149 CR749533 M24559 S43437 S43441 S43442 S43443 S43444 S43445 S43446 S43447 S43448 S43449 S62403
GenPept AAA36102 AAB20203 AAB23176 AAN65630 CAH18339
RNA Seq Atlas 5284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca