InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIGR

Summary

InnateDB Protein

IDBP-106297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIGR

Protein Name

polymeric immunoglobulin receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000348888

InnateDB Gene

IDBG-106295 (PIGR)

Protein Structure

UniProt Annotation

Function

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Secretory component: Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001792	polymeric immunoglobulin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001895	retina homeostasis
GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0038093	Fc receptor signaling pathway
GO:0043113	receptor clustering

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome