InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: C4BPA

Summary

InnateDB Gene

IDBG-106328.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C4BPA

Gene Name

complement component 4 binding protein, alpha

Synonyms

C4BP; PRP

Species

Homo sapiens

Ensembl Gene

ENSG00000123838

Encoded Proteins

IDBP-106330

complement component 4 binding protein, alpha

IDBP-389977

complement component 4 binding protein, alpha

IDBP-389978

complement component 4 binding protein, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21283780

C4BPA plays an inhibitory role in antimicrobial response by delaying the classical complement activation and attenuating the lectin pathway activation. The major inhibitory role of C4BPA is to facilitate the decay of C3 convertase.

Entrez Gene

Summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:207104262-207144972

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000367070	ENSP00000356037
ENST00000421786	ENSP00000403386
ENST00000424088	ENSP00000395968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006958	complement activation, classical pathway
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)
GO:0045732	positive regulation of protein catabolic process
GO:0045959	negative regulation of complement activation, classical pathway
GO:1903027	regulation of opsonization

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0044216	other organism cell
GO:0072562	blood microparticle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_118707

Regulation of Complement cascade pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

REACT_6932

Complement cascade pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

INOH

PID NCI

cd40_pathway

CD40/CD40L signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1012

RefSeq

NM_000715 XM_005273251 XM_005273252

HUGO

OMIM

CCDS

CCDS1477

HPRD

00403

IMGT

EMBL

GenPept

RNA Seq Atlas