InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C4BPA

Summary

InnateDB Protein

IDBP-106330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C4BPA

Protein Name

complement component 4 binding protein, alpha

Synonyms

C4BP; PRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000356037

InnateDB Gene

IDBG-106328 (C4BPA)

Protein Structure

UniProt Annotation

Function

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Chylomicrons in the plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006958	complement activation, classical pathway
GO:0030449	regulation of complement activation
GO:0045087	innate immune response (InnateDB)
GO:0045732	positive regulation of protein catabolic process
GO:0045959	negative regulation of complement activation, classical pathway
GO:1903027	regulation of opsonization