Version 5.4
Homo sapiens Gene: CD46
Summary
InnateDB Gene IDBG-106372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD46
Gene Name CD46 molecule, complement regulatory protein
Synonyms AHUS2; MCP; MIC10; TLX; TRA2.10
Species Homo sapiens
Ensembl Gene ENSG00000117335
Encoded Proteins
IDBP-106374
CD46 molecule, complement regulatory protein
IDBP-106376
CD46 molecule, complement regulatory protein
IDBP-106378
CD46 molecule, complement regulatory protein
IDBP-106380
CD46 molecule, complement regulatory protein
IDBP-106384
CD46 molecule, complement regulatory protein
IDBP-106386
CD46 molecule, complement regulatory protein
IDBP-106388
CD46 molecule, complement regulatory protein
IDBP-106390
CD46 molecule, complement regulatory protein
IDBP-106392
CD46 molecule, complement regulatory protein
IDBP-476083
CD46 molecule, complement regulatory protein
IDBP-810681
CD46 molecule, complement regulatory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20087059
CD46 is a cell surface pathogen receptor that induces autophagy upon pathogen recognition and this CD46-dependent autophagy is critical for early control of the infection.
PMID 15919905
CD46 is a ubiquitously expressed membrane protein that regulates complement activation, as a cellular attachment receptor of several pathogens, including measles virus, Neisseria gonorrhea, adenovirus and human herpesvirus 6.
PMID 18573902
CD46 enhances bacterial survival and represents a novel pathogenic mechanism that contributes to the severity of group A streptococcal disease.
PMID 16888016
CD46 acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli.
PMID 16087667
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells, whereby the complement innate immune system is using two synergistic strategies with the recognition of altered self-nucleic acids (NA) and missing self-CD46 signals to instruct and tailor the efficient removal of apoptotic and necrotic cells in immunoprivileged sites.
PMID 21488871
CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. CD46 has a vital role in preventing complement deposition on host tissue, and the resulting auto-immunity.
InnateDB Annotation from Orthologs
Summary
PMID 10233938
[Mus musculus] Cd46 enhances nitric oxide production in mouse macrophages in response to measles virus infection in the presence of gamma interferon.
PMID 21488871
[Mus musculus] Cd46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Cd46 has a vital role in preventing complement deposition on host tissue, and the resulting auto-immunity.
Entrez Gene
Summary The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:207752057-207795513
Strand Forward strand
Band q32.2
Transcripts
ENST00000358170 ENSP00000350893
ENST00000367042 ENSP00000356009
ENST00000367041 ENSP00000356008
ENST00000322875 ENSP00000313875
ENST00000354848 ENSP00000346912
ENST00000357714 ENSP00000350346
ENST00000360212 ENSP00000353342
ENST00000322918 ENSP00000314664
ENST00000367047 ENSP00000356014
ENST00000469535
ENST00000493796
ENST00000480003 ENSP00000418471
ENST00000464082
ENST00000496723
ENST00000488596
ENST00000490278
ENST00000471987
ENST00000462968 ENSP00000473449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0045296 cadherin binding
Biological Process
GO:0002250 adaptive immune response
GO:0002456 T cell mediated immunity
GO:0006958 complement activation, classical pathway
GO:0007338 single fertilization
GO:0008593 regulation of Notch signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016032 viral process
GO:0030449 regulation of complement activation
GO:0032613 interleukin-10 production
GO:0032733 positive regulation of interleukin-10 production
GO:0035581 sequestering of extracellular ligand from receptor
GO:0042102 positive regulation of T cell proliferation
GO:0043382 positive regulation of memory T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0071636 positive regulation of transforming growth factor beta production
Cellular Component
GO:0002079 inner acrosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000016493
View Gene Order
Pathways
NETPATH
REACTOME
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.510402
RefSeq NM_002389 NM_153826 NM_172350 NM_172351 NM_172352 NM_172353 NM_172359 NM_172361
HUGO
OMIM
CCDS CCDS1479 CCDS1480 CCDS1481 CCDS1482 CCDS1484 CCDS1485 CCDS31008 CCDS31009
HPRD 00406
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca