InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd46

Summary

InnateDB Gene

IDBG-209330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd46

Gene Name

CD46 antigen, complement regulatory protein

Synonyms

Mcp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016493

Encoded Proteins

IDBP-209332

CD46 antigen, complement regulatory protein

IDBP-541232

CD46 antigen, complement regulatory protein

IDBP-533339

CD46 antigen, complement regulatory protein

IDBP-542661

CD46 antigen, complement regulatory protein

IDBP-535623

CD46 antigen, complement regulatory protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 10233938

Cd46 enhances nitric oxide production in mouse macrophages in response to measles virus infection in the presence of gamma interferon.

PMID 21488871

Cd46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Cd46 has a vital role in preventing complement deposition on host tissue, and the resulting auto-immunity.

InnateDB Annotation from Orthologs

Summary

PMID 20087059

[Homo sapiens] CD46 is a cell surface pathogen receptor that induces autophagy upon pathogen recognition and this CD46-dependent autophagy is critical for early control of the infection.

PMID 15919905

[Homo sapiens] CD46 is a ubiquitously expressed membrane protein that regulates complement activation, as a cellular attachment receptor of several pathogens, including measles virus, Neisseria gonorrhea, adenovirus and human herpesvirus 6.

PMID 18573902

[Homo sapiens] CD46 enhances bacterial survival and represents a novel pathogenic mechanism that contributes to the severity of group A streptococcal disease.

PMID 16888016

[Homo sapiens] CD46 acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli.

PMID 16087667

[Homo sapiens] CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells, whereby the complement innate immune system is using two synergistic strategies with the recognition of altered self-nucleic acids (NA) and missing self-CD46 signals to instruct and tailor the efficient removal of apoptotic and necrotic cells in immunoprivileged sites.

PMID 21488871

[Homo sapiens] CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. CD46 has a vital role in preventing complement deposition on host tissue, and the resulting auto-immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117335:
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:195041285-195092248

Strand

Reverse strand

Band

Transcripts

ENSMUST00000016637	ENSMUSP00000016637
ENSMUST00000162650	ENSMUSP00000123931
ENSMUST00000160817	ENSMUSP00000124907
ENSMUST00000162614	ENSMUSP00000125140
ENSMUST00000159563	ENSMUSP00000123901
ENSMUST00000161772
ENSMUST00000162951

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding

Biological Process

GO:0006508	proteolysis
GO:0007338	single fertilization
GO:0045087	innate immune response (InnateDB)
GO:0045916	negative regulation of complement activation

Cellular Component

GO:0002079	inner acrosomal membrane
GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane