Version 5.4
Homo sapiens Gene: DUSP10
Summary
InnateDB Gene IDBG-106785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP10
Gene Name dual specificity phosphatase 10
Synonyms MKP-5; MKP5
Species Homo sapiens
Ensembl Gene ENSG00000143507
Encoded Proteins
IDBP-106787
dual specificity phosphatase 10
IDBP-809137
dual specificity phosphatase 10
IDBP-809143
dual specificity phosphatase 10
IDBP-809146
dual specificity phosphatase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22307906
DUSP10 protects against sepsis-induced acute lung injury. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22307906
[Mus musculus] Dusp10 protects against sepsis-induced acute lung injury.
Entrez Gene
Summary Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:221701424-221742176
Strand Reverse strand
Band q41
Transcripts
ENST00000366899 ENSP00000355866
ENST00000468085 ENSP00000483812
ENST00000477026 ENSP00000482935
ENST00000494642 ENSP00000480008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0033549 MAP kinase phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0002819 regulation of adaptive immune response
GO:0006470 protein dephosphorylation
GO:0006950 response to stress
GO:0007254 JNK cascade
GO:0010033 response to organic substance
GO:0016311 dephosphorylation
GO:0032496 response to lipopolysaccharide
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0043508 negative regulation of JUN kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0046329 negative regulation of JNK cascade
GO:0048709 oligodendrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039384
View Gene Order
ENSBTAG00000001729
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
atf2_pathway
ATF-2 transcription factor network
p38alphabetapathway
Regulation of p38-alpha and p38-beta
Cross-References
SwissProt Q9Y6W6
TrEMBL
UniProt Splice Variant
Entrez Gene 11221
UniGene Hs.497822 Hs.596984
RefSeq NM_007207
HUGO HGNC:3065
OMIM 608867
CCDS CCDS1528
HPRD
IMGT
EMBL AB026436 AF179212 AK022513 AL590966 BC020608 BC031405 BC063826 CH471100
GenPept AAD51857 AAH20608 AAH31405 AAH63826 BAA81668 BAB14070 CAH71120 EAW93283 EAW93285 EAW93286 EAW93287
RNA Seq Atlas 11221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca