InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP10

Summary

InnateDB Protein

IDBP-106787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP10

Protein Name

dual specificity phosphatase 10

Synonyms

MKP-5; MKP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000355866

InnateDB Gene

IDBG-106785 (DUSP10)

Protein Structure

UniProt Annotation

Function

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. {ECO:0000269PubMed:22375048}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Detected in brain. {ECO:0000269PubMed:16806267}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0033549	MAP kinase phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0002819	regulation of adaptive immune response
GO:0006470	protein dephosphorylation
GO:0006950	response to stress
GO:0007254	JNK cascade
GO:0010033	response to organic substance
GO:0016311	dephosphorylation
GO:0032496	response to lipopolysaccharide
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043508	negative regulation of JUN kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0046329	negative regulation of JNK cascade
GO:0048709	oligodendrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0060266	negative regulation of respiratory burst involved in inflammatory response

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782
PF00200
PF00581

PRINTS

PR00289
PR01764
PR01908

PIRSF

PIRSF000939

SMART

SM00050
SM00450
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References