Version 5.4
Homo sapiens Gene: TP53BP2
Summary
InnateDB Gene IDBG-106878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP53BP2
Gene Name tumor protein p53 binding protein, 2
Synonyms 53BP2; ASPP2; BBP; P53BP2; PPP1R13A
Species Homo sapiens
Ensembl Gene ENSG00000143514
Encoded Proteins
IDBP-106882
tumor protein p53 binding protein, 2
IDBP-246799
tumor protein p53 binding protein, 2
IDBP-484177
tumor protein p53 binding protein, 2
IDBP-484605
tumor protein p53 binding protein, 2
IDBP-477888
tumor protein p53 binding protein, 2
IDBP-484803
tumor protein p53 binding protein, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:223779899-223845972
Strand Reverse strand
Band q41
Transcripts
ENST00000343537 ENSP00000341957
ENST00000391878 ENSP00000375750
ENST00000483398 ENSP00000417174
ENST00000498843
ENST00000494100 ENSP00000420225
ENST00000464656 ENSP00000417987
ENST00000489310
ENST00000490896
ENST00000481128
ENST00000464172
ENST00000496282
ENST00000473135
ENST00000465119 ENSP00000418252
ENST00000472180
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 72 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0042802 identical protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0009792 embryo development ending in birth or egg hatching
GO:0009967 positive regulation of signal transduction
GO:0010212 response to ionizing radiation
GO:0045786 negative regulation of cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026510
View Gene Order
ENSBTAG00000012781
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523968 Hs.708253
RefSeq NM_001031685 NM_005426 XM_005273246
HUGO
OMIM
CCDS CCDS1538 CCDS44319
HPRD 11803
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca