InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: H3F3A

Summary

InnateDB Gene

IDBG-107003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H3F3A

Gene Name

H3 histone, family 3A

Synonyms

H3.3A; H3.3B; H3F3

Species

Homo sapiens

Ensembl Gene

ENSG00000163041

Encoded Proteins

IDBP-107005

H3 histone, family 3A

IDBP-107007

H3 histone, family 3A

IDBP-107009

H3 histone, family 3A

IDBP-107011

H3 histone, family 3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is poyadenylated, unlike most histone genes. The protein encoded is a member of the histone H3 family. [provided by RefSeq, Jul 2008] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:226061851-226072001

Strand

Forward strand

Band

q42.12

Transcripts

ENST00000366816	ENSP00000355781
ENST00000366815	ENSP00000355780
ENST00000366814	ENSP00000355779
ENST00000366813	ENSP00000355778

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.

Experimentally validated
Total	110 [view]
Protein-Protein	103 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0007596	blood coagulation
GO:0030307	positive regulation of cell growth

Cellular Component

GO:0000228	nuclear chromosome
GO:0000786	nucleosome
GO:0000788	nuclear nucleosome
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome