InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: H3F3A

Summary

InnateDB Protein

IDBP-107005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H3F3A

Protein Name

H3 histone, family 3A

Synonyms

H3.3A; H3.3B; H3F3;

Species

Homo sapiens

Ensembl Protein

ENSP00000355781

InnateDB Gene

IDBG-107003 (H3F3A)

Protein Structure

UniProt Annotation

Function

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269PubMed:14718166, ECO:0000269PubMed:15776021, ECO:0000269PubMed:16258499}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.

Experimentally validated
Total	110 [view]
Protein-Protein	103 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0007596	blood coagulation
GO:0030307	positive regulation of cell growth

Cellular Component

GO:0000228	nuclear chromosome
GO:0000786	nucleosome
GO:0000788	nuclear nucleosome
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome