Version 5.4
Homo sapiens Gene: ADAM21
Summary
InnateDB Gene IDBG-10732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM21
Gene Name ADAM metallopeptidase domain 21
Synonyms ADAM 21; ADAM31
Species Homo sapiens
Ensembl Gene ENSG00000139985
Encoded Proteins
IDBP-809290
ADAM metallopeptidase domain 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70452157-70459899
Strand Forward strand
Band q24.2
Transcripts
ENST00000603540 ENSP00000474385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0032504 multicellular organism reproduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008438
View Gene Order
ENSBTAG00000003715
Not yet available
Pathways
NETPATH
REACTOME
REACT_163933
Interaction With The Zona Pellucida pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UKJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 8747
UniGene
RefSeq NM_003813
HUGO HGNC:200
OMIM 603713
CCDS CCDS9804
HPRD
IMGT
EMBL AF029900 AF158644 AL357153 AL391223 BC109024 BC109025
GenPept AAC52042 AAD55255 AAI09025 AAI09026
RNA Seq Atlas 8747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca