Version 5.4
Homo sapiens Protein: ADAM21
Summary
InnateDB Protein IDBP-809290.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM21
Protein Name ADAM metallopeptidase domain 21
Synonyms ADAM 21; ADAM31;
Species Homo sapiens
Ensembl Protein ENSP00000474385
InnateDB Gene IDBG-10732 (ADAM21)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0032504 multicellular organism reproduction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
PFAM PF01421
PF00200
PF01562
PF08516
PRINTS PR00289
PIRSF
SMART SM00050
SM00608
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKJ8
PhosphoSite PhosphoSite-Q9UKJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 8747
UniGene
RefSeq NP_003804
HUGO HGNC:200
OMIM 603713
CCDS CCDS9804
HPRD
IMGT
EMBL AF029900 AF158644 AL357153 AL391223 BC109024 BC109025
GenPept AAC52042 AAD55255 AAI09025 AAI09026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca