Version 5.4
Homo sapiens Gene: KCNK1
Summary
InnateDB Gene IDBG-107491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK1
Gene Name potassium channel, subfamily K, member 1
Synonyms DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1; TWIK1
Species Homo sapiens
Ensembl Gene ENSG00000135750
Encoded Proteins
IDBP-107493
potassium channel, subfamily K, member 1
IDBP-390147
potassium channel, subfamily K, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:233614004-233672512
Strand Forward strand
Band q42.2
Transcripts
ENST00000366621 ENSP00000355580
ENST00000366620
ENST00000446915 ENSP00000409626
ENST00000472190
ENST00000487728
ENST00000472869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005267 potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0035094 response to nicotine
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033998
View Gene Order
ENSBTAG00000004515
Not yet available
Pathways
NETPATH
REACTOME
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75779
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.739160
RefSeq NM_002245
HUGO
OMIM
CCDS CCDS1599
HPRD 03447
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca