Version 5.4
Homo sapiens Gene: GGPS1
Summary
InnateDB Gene IDBG-107543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGPS1
Gene Name geranylgeranyl diphosphate synthase 1
Synonyms GGPPS; GGPPS1
Species Homo sapiens
Ensembl Gene ENSG00000152904
Encoded Proteins
IDBP-107545
geranylgeranyl diphosphate synthase 1
IDBP-107547
geranylgeranyl diphosphate synthase 1
IDBP-246849
geranylgeranyl diphosphate synthase 1
IDBP-475685
geranylgeranyl diphosphate synthase 1
IDBP-484509
geranylgeranyl diphosphate synthase 1
IDBP-477335
geranylgeranyl diphosphate synthase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:235327350-235344532
Strand Forward strand
Band q42.3
Transcripts
ENST00000358966 ENSP00000351852
ENST00000282841 ENSP00000282841
ENST00000391855 ENSP00000375728
ENST00000488594 ENSP00000418690
ENST00000471812 ENSP00000417772
ENST00000482013
ENST00000489692
ENST00000497327 ENSP00000417865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006720 isoprenoid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021302
View Gene Order
ENSBTAG00000013068
Not yet available
Pathways
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A8MVQ8
UniProt Splice Variant
Entrez Gene 9453
UniGene Hs.730768
RefSeq NM_001037277
HUGO HGNC:4249
OMIM 606982
CCDS CCDS1604
HPRD 06099
IMGT
EMBL AK293278 AL391994 CH471098
GenPept BAH11480 EAW70018 EAW70020
RNA Seq Atlas 9453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca