Version 5.4
Bos taurus Gene: GGPS1
Summary
InnateDB Gene IDBG-628485.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGPS1
Gene Name Geranylgeranyl pyrophosphate synthase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013068
Encoded Proteins
IDBP-679850
Geranylgeranyl pyrophosphate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152904:
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:8111377-8123251
Strand Forward strand
Band
Transcripts
ENSBTAT00000017376 ENSBTAP00000017376
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006720 isoprenoid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000152904
View Gene Order
ENSMUSG00000021302
View Gene Order
Pathways
NETPATH
REACTOME
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_223232
Activation of gene expression by SREBF (SREBP) pathway
REACT_219139
Metabolism pathway
REACT_208174
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_202983
Cholesterol biosynthesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_208531
Cholesterol biosynthesis pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
mmu00900
Terpenoid backbone biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt P56966
TrEMBL
UniProt Splice Variant
Entrez Gene 780882
UniGene Bt.71777
RefSeq NM_001079801
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120313
GenPept AAI20314
RNA Seq Atlas 780882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca