Version 5.4
Homo sapiens Gene: CHML
Summary
InnateDB Gene IDBG-107706.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHML
Gene Name choroideremia-like (Rab escort protein 2)
Synonyms REP2
Species Homo sapiens
Ensembl Gene ENSG00000203668
Encoded Proteins
IDBP-107708
choroideremia-like (Rab escort protein 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:241628853-241635930
Strand Reverse strand
Band q43
Transcripts
ENST00000366553 ENSP00000355511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005096 GTPase activator activity
GO:0017137 Rab GTPase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0018344 protein geranylgeranylation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005829 cytosol
GO:0005968 Rab-protein geranylgeranyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078185
View Gene Order
ENSBTAG00000010803
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596033 Hs.607130 Hs.654545
RefSeq NM_001821
HUGO
OMIM
CCDS CCDS31073
HPRD 00341
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca