Version 5.4
Homo sapiens Protein: CHML
Summary
InnateDB Protein IDBP-107708.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHML
Protein Name choroideremia-like (Rab escort protein 2)
Synonyms REP2;
Species Homo sapiens
Ensembl Protein ENSP00000355511
InnateDB Gene IDBG-107706 (CHML)
Protein Structure
UniProt Annotation
Function Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. {ECO:0000269PubMed:12356470, ECO:0000269PubMed:15186776, ECO:0000269PubMed:8294464}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:12356470}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005096 GTPase activator activity
GO:0017137 Rab GTPase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0018344 protein geranylgeranylation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005829 cytosol
GO:0005968 Rab-protein geranylgeranyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR001738 Rab escort (choroideraemia) protein
IPR016664 Rab protein geranylgeranyltransferase component A, eukaryota
IPR018203 GDP dissociation inhibitor
PFAM PF00996
PRINTS PR00893
PR00891
PIRSF PIRSF016550
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26374
PhosphoSite PhosphoSite-P26374
TrEMBL
UniProt Splice Variant
Entrez Gene 1122
UniGene Hs.654545
RefSeq NP_001812
HUGO HGNC:1941
OMIM 118825
CCDS CCDS31073
HPRD 00341
IMGT
EMBL AF482426 AK314125 AL133390 BC117360 CH471098 X64728
GenPept AAI17361 AAO15716 BAG36816 CAA45979 EAW70100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca