Version 5.4
Homo sapiens Gene: MAP1LC3C
Summary
InnateDB Gene IDBG-107725.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP1LC3C
Gene Name microtubule-associated protein 1 light chain 3 gamma
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197769
Encoded Proteins
IDBP-107727
microtubule-associated protein 1 light chain 3 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23022382
MAP1LC3C (LC3C) and its receptor CALCOCO2 (NDP52) are essential for antibacterial autophagy.
Entrez Gene
Summary Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:241995490-241999073
Strand Reverse strand
Band q43
Transcripts
ENST00000357246 ENSP00000349785
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005874 microtubule
GO:0012505 endomembrane system
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9BXW4
TrEMBL
UniProt Splice Variant
Entrez Gene 440738
UniGene Hs.534971
RefSeq NM_001004343 XM_005273139
HUGO HGNC:13353
OMIM 609605
CCDS CCDS31074
HPRD
IMGT
EMBL AF276659 BC127722 BC132986 BC132988 BX571673
GenPept AAI27723 AAI32987 AAI32989 AAK35152 CAH72477
RNA Seq Atlas 440738

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca