Version 5.4
Homo sapiens Protein: MAP1LC3C
Summary
InnateDB Protein IDBP-107727.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP1LC3C
Protein Name microtubule-associated protein 1 light chain 3 gamma
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349785
InnateDB Gene IDBG-107725 (MAP1LC3C)
Protein Structure
UniProt Annotation
Function Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium. {ECO:0000269PubMed:23022382}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:12740394}. Endomembrane system {ECO:0000269PubMed:12740394}; Lipid-anchor {ECO:0000269PubMed:12740394}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269PubMed:12740394}; Lipid-anchor {ECO:0000269PubMed:12740394}. Note=LC3-II binds to the autophagic membranes.
Disease Associations
Tissue Specificity Most abundant in placenta, lung and ovary. {ECO:0000269PubMed:12740394}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006914 autophagy
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005874 microtubule
GO:0012505 endomembrane system
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR004241 Autophagy protein Atg8 ubiquitin like
IPR007242 Ubiquitin-like protein Atg12
IPR029071 Ubiquitin-related domain
PFAM PF02991
PF04110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXW4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 440738
UniGene Hs.534971
RefSeq NP_001004343
HUGO HGNC:13353
OMIM 609605
CCDS CCDS31074
HPRD 14226
IMGT
EMBL AF276659 BC127722 BC132986 BC132988 BX571673
GenPept AAI27723 AAI32987 AAI32989 AAK35152 CAH72477

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca