Version 5.4
Homo sapiens Gene: RGS6
Summary
InnateDB Gene IDBG-11010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS6
Gene Name regulator of G-protein signaling 6
Synonyms GAP
Species Homo sapiens
Ensembl Gene ENSG00000182732
Encoded Proteins
IDBP-11012
regulator of G-protein signaling 6
IDBP-11014
regulator of G-protein signaling 6
IDBP-293359
regulator of G-protein signaling 6
IDBP-293350
regulator of G-protein signaling 6
IDBP-293353
regulator of G-protein signaling 6
IDBP-293345
regulator of G-protein signaling 6
IDBP-373650
regulator of G-protein signaling 6
IDBP-585210
regulator of G-protein signaling 6
IDBP-587830
regulator of G-protein signaling 6
IDBP-589533
regulator of G-protein signaling 6
IDBP-601852
regulator of G-protein signaling 6
IDBP-583542
regulator of G-protein signaling 6
IDBP-600578
regulator of G-protein signaling 6
IDBP-809916
regulator of G-protein signaling 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:71932439-72566529
Strand Forward strand
Band q24.2
Transcripts
ENST00000355512 ENSP00000347699
ENST00000343854 ENSP00000341199
ENST00000407322 ENSP00000384612
ENST00000402788 ENSP00000383953
ENST00000406236 ENSP00000384218
ENST00000404301 ENSP00000385243
ENST00000434263 ENSP00000412144
ENST00000553525 ENSP00000451030
ENST00000555571 ENSP00000450936
ENST00000553530 ENSP00000452331
ENST00000554474 ENSP00000450858
ENST00000556437 ENSP00000451855
ENST00000553690
ENST00000555368
ENST00000554782 ENSP00000451912
ENST00000554734
ENST00000553519
ENST00000554300
ENST00000622468 ENSP00000478186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0045666 positive regulation of neuron differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021219
View Gene Order
ENSBTAG00000014189
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.509872 Hs.691122 Hs.731313
RefSeq NM_001204416 NM_001204417 NM_001204418 NM_001204419 NM_001204420 NM_001204421 NM_001204422 NM_001204423 NM_001204424 NM_004296 XM_005268235 XM_005268236 XM_006720328 XM_006720329 XM_006720330 XM_006720331
HUGO
OMIM
CCDS CCDS55924 CCDS73655 CCDS9808
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca