InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs6

Summary

InnateDB Gene

IDBG-155067.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs6

Gene Name

regulator of G-protein signaling 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021219

Encoded Proteins

IDBP-155071

regulator of G-protein signaling 6

IDBP-541272

regulator of G-protein signaling 6

IDBP-787822

regulator of G-protein signaling 6

IDBP-787823

regulator of G-protein signaling 6

IDBP-787824

regulator of G-protein signaling 6

IDBP-787825

regulator of G-protein signaling 6

IDBP-787826

regulator of G-protein signaling 6

IDBP-787827

regulator of G-protein signaling 6

IDBP-787828

regulator of G-protein signaling 6

IDBP-787829

regulator of G-protein signaling 6

IDBP-787830

regulator of G-protein signaling 6

IDBP-787831

regulator of G-protein signaling 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182732:
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:82616925-83162056

Strand

Forward strand

Band

Transcripts

ENSMUST00000101234	ENSMUSP00000098793
ENSMUST00000161801	ENSMUSP00000125256
ENSMUST00000185665	ENSMUSP00000139566
ENSMUST00000186458	ENSMUSP00000139735
ENSMUST00000186309	ENSMUSP00000140701
ENSMUST00000186081	ENSMUSP00000140188
ENSMUST00000191311	ENSMUSP00000140723
ENSMUST00000191352	ENSMUSP00000139718
ENSMUST00000191107	ENSMUSP00000139725
ENSMUST00000186323	ENSMUSP00000141079
ENSMUST00000185674	ENSMUSP00000139940
ENSMUST00000190964
ENSMUST00000186848	ENSMUSP00000141044

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0045666	positive regulation of neuron differentiation