Version 5.4
Homo sapiens Gene: DCAF4
Summary
InnateDB Gene IDBG-11136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF4
Gene Name DDB1 and CUL4 associated factor 4
Synonyms WDR21; WDR21A
Species Homo sapiens
Ensembl Gene ENSG00000119599
Encoded Proteins
IDBP-11138
DDB1 and CUL4 associated factor 4
IDBP-11142
DDB1 and CUL4 associated factor 4
IDBP-241996
DDB1 and CUL4 associated factor 4
IDBP-473454
DDB1 and CUL4 associated factor 4
IDBP-482187
DDB1 and CUL4 associated factor 4
IDBP-584704
DDB1 and CUL4 associated factor 4
IDBP-586479
DDB1 and CUL4 associated factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:72926332-72959703
Strand Forward strand
Band q24.2
Transcripts
ENST00000358377 ENSP00000351147
ENST00000353777 ENSP00000345176
ENST00000394234 ENSP00000377781
ENST00000509320 ENSP00000422270
ENST00000509153 ENSP00000426178
ENST00000514191
ENST00000505361
ENST00000510612
ENST00000508412
ENST00000514486
ENST00000513337
ENST00000555042 ENSP00000452131
ENST00000553457 ENSP00000451186
ENST00000557203
ENST00000555992
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021222
View Gene Order
ENSBTAG00000008713
Not yet available
Cross-References
SwissProt Q8WV16
TrEMBL D6RCB5 G3V3D6 Q86SY2
UniProt Splice Variant
Entrez Gene 26094
UniGene Hs.331491 Hs.742751
RefSeq NM_001163508 NM_001163509 NM_015604 NM_181340 NM_181341 XM_005267524
HUGO HGNC:20229
OMIM
CCDS CCDS41968 CCDS55926 CCDS9809 CCDS9810
HPRD
IMGT
EMBL AC007160 AK027745 AK300786 AL080157 AL442663 BC018979 BC035901 BX161489 BX247962 CH471061
GenPept AAH18979 AAH35901 BAB55337 BAG62448 CAB45748 CAD61938 CAD62301 EAW81083
RNA Seq Atlas 26094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca