Version 5.4
Homo sapiens Protein: DCAF4
Summary
InnateDB Protein IDBP-482187.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCAF4
Protein Name DDB1 and CUL4 associated factor 4
Synonyms WDR21; WDR21A;
Species Homo sapiens
Ensembl Protein ENSP00000426178
InnateDB Gene IDBG-11136 (DCAF4)
Protein Structure
UniProt Annotation
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269PubMed:16949367, ECO:0000269PubMed:16964240}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WV16
PhosphoSite PhosphoSite-Q8WV16
TrEMBL
UniProt Splice Variant
Entrez Gene 26094
UniGene Hs.742751
RefSeq NP_851938
HUGO HGNC:20229
OMIM
CCDS CCDS41968
HPRD 15664
IMGT
EMBL AC007160 AK027745 AK300786 AL080157 AL442663 BC018979 BC035901 BX247962
GenPept AAH18979 AAH35901 BAB55337 BAG62448 CAB45748 CAD62301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca