Version 5.4
Homo sapiens Gene: RAD52
Summary
InnateDB Gene IDBG-11610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD52
Gene Name RAD52 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000002016
Encoded Proteins
IDBP-11614
RAD52 homolog (S. cerevisiae)
IDBP-235799
RAD52 homolog (S. cerevisiae)
IDBP-360898
RAD52 homolog (S. cerevisiae)
IDBP-601611
RAD52 homolog (S. cerevisiae)
IDBP-597632
RAD52 homolog (S. cerevisiae)
IDBP-596727
RAD52 homolog (S. cerevisiae)
IDBP-602849
RAD52 homolog (S. cerevisiae)
IDBP-594025
RAD52 homolog (S. cerevisiae)
IDBP-587288
RAD52 homolog (S. cerevisiae)
IDBP-589057
RAD52 homolog (S. cerevisiae)
IDBP-590176
RAD52 homolog (S. cerevisiae)
IDBP-589768
RAD52 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. [provided by RefSeq, Jul 2008]
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:912077-990053
Strand Reverse strand
Band p13.33
Transcripts
ENST00000228345
ENST00000358495 ENSP00000351284
ENST00000397230 ENSP00000380407
ENST00000430095 ENSP00000387901
ENST00000468231 ENSP00000434703
ENST00000481052
ENST00000488642
ENST00000461568 ENSP00000436008
ENST00000463750
ENST00000535376
ENST00000542297
ENST00000543912 ENSP00000439583
ENST00000536177 ENSP00000440486
ENST00000542584
ENST00000545967
ENST00000542785 ENSP00000441073
ENST00000544742 ENSP00000443254
ENST00000541619 ENSP00000438965
ENST00000545629
ENST00000539259
ENST00000543290
ENST00000539046 ENSP00000445245
ENST00000545564 ENSP00000440268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000730 DNA recombinase assembly
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030166
View Gene Order
ENSBTAG00000005225
Not yet available
Pathways
NETPATH
REACTOME
REACT_2141
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
REACT_408
Presynaptic phase of homologous DNA pairing and strand exchange pathway
REACT_1763
Homologous DNA pairing and strand exchange pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_216
DNA Repair pathway
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt P43351
TrEMBL F5GX95 Q9UHE2
UniProt Splice Variant
Entrez Gene 5893
UniGene Hs.410355 Hs.560083
RefSeq NM_001297420 NM_001297419 NM_001297422 NM_134424 XM_005253720 XM_005253721 XM_005253725
HUGO HGNC:9824
OMIM 600392
CCDS CCDS8507
HPRD 11855
IMGT
EMBL AC004803 AF125948 AF125949 AF125950 AF187983 AK292160 AK312026 AY527412 CH471116 L33262 U12134 U27516
GenPept AAA85793 AAA87554 AAB05203 AAD24575 AAD24576 AAD24577 AAF05532 AAS00097 BAF84849 BAG34963 EAW88943 EAW88945 EAW88946 EAW88949
RNA Seq Atlas 5893

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca