Version 5.4
Bos taurus Gene: RAD52
Summary
InnateDB Gene IDBG-641049.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD52
Gene Name DNA repair protein RAD52 homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005225
Encoded Proteins
IDBP-693373
DNA repair protein RAD52 homolog
IDBP-693375
DNA repair protein RAD52 homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002016:
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. [provided by RefSeq, Jul 2008]
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:108209678-108235391
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006880 ENSBTAP00000006880
ENSBTAT00000055617 ENSBTAP00000052915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000002016
View Gene Order
ENSMUSG00000030166
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_2141
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
REACT_408
Presynaptic phase of homologous DNA pairing and strand exchange pathway
REACT_1763
Homologous DNA pairing and strand exchange pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_216
DNA Repair pathway
REACT_261855
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_243723
Homologous DNA pairing and strand exchange pathway
REACT_235085
Presynaptic phase of homologous DNA pairing and strand exchange pathway
REACT_233397
DNA Repair pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
hsa03440
Homologous recombination pathway
mmu03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2VE43 F1MM43
UniProt Splice Variant
Entrez Gene 512897
UniGene Bt.20457
RefSeq NM_001024525 XM_005207234 XM_005207235 XM_005207236 XM_005207237 XM_005207238
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133563 DAAA02014592
GenPept AAI33564
RNA Seq Atlas 512897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca