Version 5.4
Homo sapiens Gene: ADIPOR2
Summary
InnateDB Gene IDBG-11908.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADIPOR2
Gene Name adiponectin receptor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006831
Encoded Proteins
IDBP-11910
adiponectin receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:1688574-1788678
Strand Forward strand
Band p13.33
Transcripts
ENST00000357103 ENSP00000349616
ENST00000537545
ENST00000540974
ENST00000543456
ENST00000535774
ENST00000544470
ENST00000537190
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0055100 adiponectin binding
Biological Process
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0009755 hormone-mediated signaling pathway
GO:0019395 fatty acid oxidation
GO:0030308 negative regulation of cell growth
GO:0033211 adiponectin-activated signaling pathway
GO:0046326 positive regulation of glucose import
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030168
View Gene Order
ENSBTAG00000009050
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371642 Hs.600531 Hs.735430
RefSeq NM_024551 XM_005253789 XM_006719018
HUGO
OMIM
CCDS CCDS8511
HPRD 06403
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca