Version 5.4
Homo sapiens Protein: ADIPOR2
Summary
InnateDB Protein IDBP-11910.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADIPOR2
Protein Name adiponectin receptor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349616
InnateDB Gene IDBG-11908 (ADIPOR2)
Protein Structure
UniProt Annotation
Function Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. {ECO:0000269PubMed:12802337}.
Subcellular Localization Membrane {ECO:0000269PubMed:12802337}; Multi-pass membrane protein {ECO:0000269PubMed:12802337}. Note=Localized to the cell membrane and intracellular organelles.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung. {ECO:0000269PubMed:12802337, ECO:0000269PubMed:16044242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
GO:0055100 adiponectin binding
Biological Process
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0009755 hormone-mediated signaling pathway
GO:0019395 fatty acid oxidation
GO:0030308 negative regulation of cell growth
GO:0033211 adiponectin-activated signaling pathway
GO:0046326 positive regulation of glucose import
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004254 Hly-III-related
PFAM PF03006
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86V24
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 79602
UniGene Hs.735430
RefSeq NP_078827
HUGO HGNC:24041
OMIM 607946
CCDS CCDS8511
HPRD 06403
IMGT
EMBL AK025085 AK127196 AK128511 AY424280 BC051858 CH471116
GenPept AAH51858 AAR08368 BAB15062 BAC86881 BAC87473 EAW88924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca