Version 5.4
Homo sapiens Gene: NKX3-1
Summary
InnateDB Gene IDBG-12113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKX3-1
Gene Name NK3 homeobox 1
Synonyms BAPX2; NKX3; NKX3.1; NKX3A
Species Homo sapiens
Ensembl Gene ENSG00000167034
Encoded Proteins
IDBP-12115
NK3 homeobox 1
IDBP-479771
NK3 homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23678693-23682927
Strand Reverse strand
Band p21.2
Transcripts
ENST00000380871 ENSP00000370253
ENST00000523261 ENSP00000429729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004882 androgen receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030284 estrogen receptor activity
GO:0030295 protein kinase activator activity
GO:0030331 estrogen receptor binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0043621 protein self-association
GO:0044212 transcription regulatory region DNA binding
GO:0097162 MADS box domain binding
Biological Process
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organismal development
GO:0007431 salivary gland development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010942 positive regulation of cell death
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030521 androgen receptor signaling pathway
GO:0030850 prostate gland development
GO:0033574 response to testosterone
GO:0035690 cellular response to drug
GO:0035907 dorsal aorta development
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043491 protein kinase B signaling
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060037 pharyngeal system development
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071383 cellular response to steroid hormone stimulus
GO:0071456 cellular response to hypoxia
GO:0071850 mitotic cell cycle arrest
GO:0071899 negative regulation of estrogen receptor binding
GO:2000836 positive regulation of androgen secretion
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022061
View Gene Order
ENSBTAG00000001221
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05215
Prostate cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt Q99801
TrEMBL
UniProt Splice Variant
Entrez Gene 4824
UniGene Hs.55999 Hs.621889
RefSeq NM_001256339 NM_006167
HUGO HGNC:7838
OMIM 602041
CCDS CCDS59095 CCDS6042
HPRD
IMGT
EMBL AF247704 AF249669 AF249670 AF249671 AF249672 BC074863 BC074864 U80669 U91540
GenPept AAB38747 AAB68662 AAG09781 AAG39735 AAG39736 AAG39737 AAG39738 AAH74863 AAH74864
RNA Seq Atlas 4824

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca