InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKX3-1

Summary

InnateDB Protein

IDBP-479771.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKX3-1

Protein Name

NK3 homeobox 1

Synonyms

BAPX2; NKX3; NKX3.1; NKX3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000429729

InnateDB Gene

IDBG-12113 (NKX3-1)

Protein Structure

UniProt Annotation

Function

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269PubMed:19462257}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:11137288}.

Disease Associations

Tissue Specificity

Highly expressed in the prostate and, at a lower level, in the testis. {ECO:0000269PubMed:9226374, ECO:0000269PubMed:9537602}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004882	androgen receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030284	estrogen receptor activity
GO:0030295	protein kinase activator activity
GO:0030331	estrogen receptor binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0043621	protein self-association
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006355	regulation of transcription, DNA-templated
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275	multicellular organismal development
GO:0007431	salivary gland development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010942	positive regulation of cell death
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030521	androgen receptor signaling pathway
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043491	protein kinase B signaling
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051781	positive regulation of cell division
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071383	cellular response to steroid hormone stimulus
GO:0071456	cellular response to hypoxia
GO:0071850	mitotic cell cycle arrest
GO:0071899	negative regulation of estrogen receptor binding
GO:2000836	positive regulation of androgen secretion
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway