InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CELSR1

Summary

InnateDB Gene

IDBG-12143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELSR1

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

Synonyms

CDHF9; FMI2; HFMI2; ME2

Species

Homo sapiens

Ensembl Gene

ENSG00000075275

Encoded Proteins

IDBP-12145

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

IDBP-380249

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:46360834-46537170

Strand

Reverse strand

Band

q13.31

Transcripts

ENST00000262738	ENSP00000262738
ENST00000454637	ENSP00000414689
ENST00000473624
ENST00000468025
ENST00000497509

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001736	establishment of planar polarity
GO:0001764	neuron migration
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007417	central nervous system development
GO:0007626	locomotory behavior
GO:0009952	anterior/posterior pattern specification
GO:0032956	regulation of actin cytoskeleton organization
GO:0042060	wound healing
GO:0042249	establishment of planar polarity of embryonic epithelium
GO:0042472	inner ear morphogenesis
GO:0045176	apical protein localization
GO:0048105	establishment of body hair planar orientation
GO:0060488	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060489	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060490	lateral sprouting involved in lung morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090251	protein localization involved in establishment of planar polarity

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000016028

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.252387 Hs.609731

RefSeq

NM_014246

HUGO

OMIM

CCDS

CCDS14076

HPRD

05160

IMGT

EMBL

GenPept

RNA Seq Atlas