Homo sapiens Gene: SHC2
Summary
InnateDB Gene IDBG-12158.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHC2
Gene Name SHC (Src homology 2 domain containing) transforming protein 2
Synonyms SCK; SHCB; SLI
Species Homo sapiens
Ensembl Gene ENSG00000129946
Encoded Proteins
SHC (Src homology 2 domain containing) transforming protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:416583-460996
Strand Reverse strand
Band p13.3
Transcripts
ENST00000264554 ENSP00000264554
ENST00000590222 ENSP00000466869
ENST00000589922
ENST00000588376
ENST00000590170 ENSP00000465764
ENST00000590113
ENST00000587423
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
IL5 pathway
REACTOME
Signalling to RAS pathway
Signal attenuation pathway
SHC-mediated signalling pathway
Signaling by Insulin receptor pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
SHC-related events pathway
Signalling by NGF pathway
Signaling by VEGF pathway
Signal Transduction pathway
Insulin receptor signalling cascade pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IGF1R signaling cascade pathway
KEGG
VEGF signaling pathway pathway
ErbB signaling pathway pathway
Glioma pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
INOH
Integrin signaling pathway pathway
IL-5 signaling pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
PID NCI
VEGFR1 specific signals
Cross-References
SwissProt P98077
TrEMBL
UniProt Splice Variant
Entrez Gene 25759
UniGene
RefSeq NM_012435 XM_005259529
HUGO HGNC:29869
OMIM 605217
CCDS CCDS45891
HPRD
IMGT
EMBL AB001451 AC006124 AC008988 AC138433 AL360254
GenPept BAA25798 CAB96175
RNA Seq Atlas 25759