Homo sapiens Protein: SHC2
Summary
InnateDB Protein IDBP-12160.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHC2
Protein Name SHC (Src homology 2 domain containing) transforming protein 2
Synonyms SCK; SHCB; SLI;
Species Homo sapiens
Ensembl Protein ENSP00000264554
InnateDB Gene IDBG-12158 (SHC2)
Protein Structure
UniProt Annotation
Function Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. {ECO:0000269PubMed:9507002}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR006019 Phosphotyrosine interaction domain, Shc-like
IPR006020 PTB/PI domain
PFAM PF00017
PF14633
PF00640
PF14719
PRINTS PR00401
PR00629
PIRSF
SMART SM00252
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P98077
PhosphoSite PhosphoSite-P98077
TrEMBL
UniProt Splice Variant
Entrez Gene 25759
UniGene
RefSeq NP_036567
HUGO HGNC:29869
OMIM 605217
CCDS CCDS45891
HPRD
IMGT
EMBL AB001451 AC006124 AC008988 AC138433 AL360254
GenPept BAA25798 CAB96175