Homo sapiens Gene: SLX4

Summary
InnateDB Gene IDBG-12161.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol SLX4
Gene Name SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms BTBD12; FANCP; MUS312
Species Homo sapiens
Ensembl Gene ENSG00000188827
Encoded Proteins
IDBP-12163 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
InnateDB Annotation
Summary
PMID 24412650 HIV auxiliary protein Vpr directly activates SLX4 to promote cell cycle arrest at the G2/M, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex, to escape from innate immune sensing.
Entrez Gene
Summary This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16: 3631182-3661599
Strand Reverse strand
Band p13.3
Transcripts
ENST00000294008  ENSP00000294008
ENST00000466154 
ENST00000486524 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
Experimentally validated
Total 59 [view]
Protein‑Protein  59
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008821 crossover junction endodeoxyribonuclease activity
GO:0017108 5'-flap endonuclease activity
GO:0048257 3'-flap endonuclease activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0000790 nuclear chromatin
GO:0033557 Slx1-Slx4 complex
GO:0048476 Holliday junction resolvase complex
GO:0070522 ERCC4-ERCC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000039738 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000004509 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8IY92 
TrEMBL
UniProt Splice Variant
Entrez Gene 84464 
UniGene Hs.143681
RefSeq NM_032444 
HUGO 23845 
OMIM 613278
CCDS CCDS10506 
HPRD 12537
IMGT
EMBL AB058687 AB075867 AC006111 AL442083
GenPept BAB47413  BAB85573  CAH10659 
ImmGen SLX4 (murine) 
RNA Seq Atlas 84464