Homo sapiens Gene: SLX4
Summary
InnateDB Gene IDBG-12161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLX4
Gene Name SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188827
Encoded Proteins
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Protein Structure
InnateDB Annotation
Summary
HIV auxiliary protein Vpr directly activates SLX4 to promote cell cycle arrest at the G2/M, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex, to escape from innate immune sensing.
Entrez Gene
Summary This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3581181-3611598
Strand Reverse strand
Band p13.3
Transcripts
ENST00000294008 ENSP00000294008
ENST00000466154
ENST00000486524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008821 crossover junction endodeoxyribonuclease activity
GO:0017108 5'-flap endonuclease activity
GO:0048257 3'-flap endonuclease activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
GO:0072429 response to intra-S DNA damage checkpoint signaling
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030054 cell junction
GO:0033557 Slx1-Slx4 complex
GO:0048476 Holliday junction resolvase complex
GO:0070522 ERCC4-ERCC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8IY92
TrEMBL
UniProt Splice Variant
Entrez Gene 84464
UniGene Hs.143681
RefSeq NM_032444
HUGO HGNC:23845
OMIM 613278
CCDS CCDS10506
HPRD 12537
IMGT
EMBL AB058687 AB075867 AC006111 AL442083
GenPept BAB47413 BAB85573 CAH10659
ImmGen SLX4 (murine)
RNA Seq Atlas 84464