InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slx4

Summary

InnateDB Gene

IDBG-129386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slx4

Gene Name

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Synonyms

AI256635; AI426760; Btbd12; D16Bwg1016e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039738

Encoded Proteins

IDBP-129388

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

IDBP-624337

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

IDBP-624344

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

IDBP-624349

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

IDBP-624351

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

IDBP-624352

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24412650

[Homo sapiens] HIV auxiliary protein Vpr directly activates SLX4 to promote cell cycle arrest at the G2/M, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex, to escape from innate immune sensing.

Entrez Gene

Summary

This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:3979105-4003770

Strand

Reverse strand

Band

Transcripts

ENSMUST00000040790	ENSMUSP00000038871
ENSMUST00000146569	ENSMUSP00000126423
ENSMUST00000156542	ENSMUSP00000130007
ENSMUST00000128980
ENSMUST00000145706
ENSMUST00000165830	ENSMUSP00000126047
ENSMUST00000171762	ENSMUSP00000131380
ENSMUST00000171658	ENSMUSP00000129144

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0048257	3'-flap endonuclease activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing
GO:0043085	positive regulation of catalytic activity
GO:0072429	response to intra-S DNA damage checkpoint signaling

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0033557	Slx1-Slx4 complex
GO:0048476	Holliday junction resolvase complex
GO:0070522	ERCC4-ERCC1 complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000188827

View Gene Order

ENSBTAG00000004509

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.29935 Mm.483308

RefSeq

NM_177472 XM_006522351

OMIM

CCDS

CCDS37240

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas