Version 5.4
Homo sapiens Gene: PI4K2B
Summary
InnateDB Gene IDBG-12178.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PI4K2B
Gene Name phosphatidylinositol 4-kinase type 2 beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000038210
Encoded Proteins
IDBP-12180
phosphatidylinositol 4-kinase type 2 beta
IDBP-474277
phosphatidylinositol 4-kinase type 2 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:25160641-25279092
Strand Forward strand
Band p15.2
Transcripts
ENST00000264864 ENSP00000264864
ENST00000510415
ENST00000512921 ENSP00000423373
ENST00000507794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004430 1-phosphatidylinositol 4-kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0016310 phosphorylation
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029186
View Gene Order
ENSBTAG00000006492
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_121168
Synthesis of PIPs at the ER membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.732278 Hs.741411
RefSeq NM_018323 XM_005248174 XM_005248175
HUGO
OMIM
CCDS CCDS3433
HPRD 15132
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca