Homo sapiens Gene: CTNND2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-12568.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CTNND2 | ||||||||||||||||||||||
Gene Name | catenin (cadherin-associated protein), delta 2 | ||||||||||||||||||||||
Synonyms | GT24; NPRAP | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000169862 | ||||||||||||||||||||||
Encoded Proteins |
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.[provided by RefSeq, Aug 2010] This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:10971840-11904043 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p15.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.314543 Hs.595576 Hs.713147 | ||||||||||||||||||||||
RefSeq | NM_001288715 NM_001288716 NM_001288717 NM_001332 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS3881 CCDS75227 CCDS75228 | ||||||||||||||||||||||
HPRD | 09181 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||