Version 5.4
Mus musculus Gene: Ctnnd2
Summary
InnateDB Gene IDBG-132442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctnnd2
Gene Name catenin (cadherin associated protein), delta 2
Synonyms Catnd2; neurojugin; Nprap
Species Mus musculus
Ensembl Gene ENSMUSG00000022240
Encoded Proteins
IDBP-132444
catenin (cadherin associated protein), delta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169862:
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.[provided by RefSeq, Aug 2010]
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:30172593-31029311
Strand Forward strand
Band B2
Transcripts
ENSMUST00000081728 ENSMUSP00000080427
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001763 morphogenesis of a branching structure
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007612 learning
GO:0016337 single organismal cell-cell adhesion
GO:0048167 regulation of synaptic plasticity
Cellular Component
GO:0005634 nucleus
GO:0005912 adherens junction
GO:0014069 postsynaptic density
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169862
View Gene Order
ENSBTAG00000017222
Not yet available
Cross-References
SwissProt O35927
TrEMBL E9QKH8 Q3TPK9 Q3U8L7 Q3UXX4
UniProt Splice Variant
Entrez Gene 18163
UniGene Mm.321648 Mm.409626
RefSeq NM_008729 XM_006520033
OMIM
CCDS CCDS27405
HPRD
IMGT
MGI ID MGI:1195966
MGI Symbol Ctnnd2
EMBL AC105408 AC110569 AC123531 AC124675 AC124993 AC134414 AC139197 AK135146 AK150491 AK152167 AK164304 BC138260 BC138261 U90331
GenPept AAB82409 AAI38261 AAI38262 BAE22439 BAE29607 BAE31000 BAE37727
RNA Seq Atlas 18163

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca