Version 5.4
Homo sapiens Gene: AOAH
Summary
InnateDB Gene IDBG-12617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AOAH
Gene Name acyloxyacyl hydrolase (neutrophil)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136250
Encoded Proteins
IDBP-372248
acyloxyacyl hydrolase (neutrophil)
IDBP-372250
acyloxyacyl hydrolase (neutrophil)
IDBP-810522
acyloxyacyl hydrolase (neutrophil)
IDBP-810526
acyloxyacyl hydrolase (neutrophil)
IDBP-810532
acyloxyacyl hydrolase (neutrophil)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:36512949-36724549
Strand Reverse strand
Band p14.2
Transcripts
ENST00000435386 ENSP00000416051
ENST00000414637 ENSP00000416472
ENST00000491444
ENST00000487014
ENST00000495942
ENST00000480201
ENST00000543742
ENST00000617537 ENSP00000483783
ENST00000621510
ENST00000617267 ENSP00000479664
ENST00000614254
ENST00000612871 ENSP00000484305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004465 lipoprotein lipase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0050528 acyloxyacyl hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006954 inflammatory response
GO:0008653 lipopolysaccharide metabolic process
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021322
View Gene Order
ENSBTAG00000018119
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.488007
RefSeq NM_001177506 NM_001177507 NM_001637
HUGO
OMIM
CCDS CCDS5448 CCDS55102 CCDS75584
HPRD 00027
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca