Version 5.4
Mus musculus Gene: Aoah
Summary
InnateDB Gene IDBG-133100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aoah
Gene Name acyloxyacyl hydrolase
Synonyms 4930433E13Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000021322
Encoded Proteins
IDBP-133102
acyloxyacyl hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:20794119-21024252
Strand Forward strand
Band A2
Transcripts
ENSMUST00000021757 ENSMUSP00000021757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016788 hydrolase activity, acting on ester bonds
GO:0050528 acyloxyacyl hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008653 lipopolysaccharide metabolic process
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136250
View Gene Order
ENSBTAG00000018119
Not yet available
Cross-References
SwissProt O35298
TrEMBL
UniProt Splice Variant
Entrez Gene 27052
UniGene Mm.314046
RefSeq NM_012054 XM_006516681 XM_006516682 XM_006516683
OMIM
CCDS CCDS26266
HPRD
IMGT
MGI ID MGI:1350928
MGI Symbol Aoah
EMBL AF018172 AK084452
GenPept AAB81182 BAC39187
RNA Seq Atlas 27052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca