Version 5.4
Homo sapiens Gene: PRMT8
Summary
InnateDB Gene IDBG-12744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT8
Gene Name protein arginine methyltransferase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111218
Encoded Proteins
IDBP-12746
protein arginine methyltransferase 8
IDBP-362165
protein arginine methyltransferase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:3381349-3593973
Strand Forward strand
Band p13.32
Transcripts
ENST00000382622 ENSP00000372067
ENST00000261252
ENST00000452611 ENSP00000414507
ENST00000543701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016740 transferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0016571 histone methylation
GO:0018216 peptidyl-arginine methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034969 histone arginine methylation
GO:0043393 regulation of protein binding
GO:0043985 histone H4-R3 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030350
View Gene Order
ENSBTAG00000009447
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.504530
RefSeq NM_001256536 NM_019854
HUGO
OMIM
CCDS CCDS58200 CCDS8521
HPRD 11029
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca