InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT8

Summary

InnateDB Protein

IDBP-12746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT8

Protein Name

protein arginine methyltransferase 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000372067

InnateDB Gene

IDBG-12744 (PRMT8)

Protein Structure

UniProt Annotation

Function

Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. {ECO:0000269PubMed:16051612, ECO:0000269PubMed:17925405, ECO:0000269PubMed:18320585}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16051612, ECO:0000269PubMed:18320585}; Lipid-anchor {ECO:0000269PubMed:16051612, ECO:0000269PubMed:18320585}; Cytoplasmic side {ECO:0000269PubMed:16051612, ECO:0000269PubMed:18320585}.

Disease Associations

Tissue Specificity

Brain-specific. {ECO:0000269PubMed:16051612}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016740	transferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034969	histone arginine methylation
GO:0043393	regulation of protein binding
GO:0043985	histone H4-R3 methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF06325
PF08241
PF05185

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NR22

PhosphoSite